2-METHYL-1-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]METHYL]-6-MORPHOLIN-4-YLBENZIMIDAZOLE-4-CARBOXYLIC ACID
GSK2636771
CAS: 1372540-25-4
Molecular Formula: C22H22F3N3O3
2-METHYL-1-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]METHYL]-6-MORPHOLIN-4-YLBENZIMIDAZOLE-4-CARBOXYLIC ACID - Names and Identifiers
2-METHYL-1-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]METHYL]-6-MORPHOLIN-4-YLBENZIMIDAZOLE-4-CARBOXYLIC ACID - Physico-chemical Properties
| Molecular Formula | C22H22F3N3O3 |
| Molar Mass | 433.42 |
| Density | 1.38 |
| Melting Point | >225°C (dec.) |
| Boling Point | 641.3±55.0 °C(Predicted) |
| Solubility | DMSO 28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | Solid |
| Color | Pale Yellow |
| pKa | -2.70±0.30(Predicted) |
| Storage Condition | -20°C Freezer |
| In vitro study | GSK-2636771 has selective inhibitory activity against PTEN-deficient cell lines (human prostate cancer PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. |
| In vivo study | These xenograft models were treated GSK-2636771 to reduce the level of the phosphorylated protein kinase Akt(Ser473). Treatment of mice with GSK-2636771(100 mg/kg) did not increase glucose/insulin levels. |
2-METHYL-1-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]METHYL]-6-MORPHOLIN-4-YLBENZIMIDAZOLE-4-CARBOXYLIC ACID - Introduction
GSK2636771 is an orally biopotent PI3Kβ selective inhibitor sensitive to PTEN deletion cell lines.
Last Update：2022-10-16 17:41:27
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Product Name: GSK2636771 Visit Supplier Webpage Request for quotation
CAS: 1372540-25-4
Tel: 18301782025
Email: 3008007409@qq.com
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QQ: 3008007409
CAS: 1372540-25-4
Tel: 18301782025
Email: 3008007409@qq.com
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View History
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